If you crave a comforting, hearty meal with a spicy, cheesy kick, this Pepperjack Meatloaf Recipe is about to become your new favorite dinner fix. Combining the classic warmth of traditional meatloaf with the bold flavors of pepperjack cheese and a little heat, this dish satisfies every craving in one easy, crowd-pleasing package. Whether it’s a family dinner or a casual weeknight treat, this recipe guarantees moist, flavorful meatloaf with that irresistible melty cheese surprise inside.

Why You’ll Love This Recipe

A flavorful twist: The pepperjack cheese adds just the right amount of spice and creaminess to classic meatloaf.
Simple ingredients: Easy-to-find pantry staples make this recipe quick and stress-free.
Perfectly moist texture: A blend of breadcrumbs and milk keeps the meatloaf tender every time.
Kid-friendly with a kick: Mild spice balanced with cheesy goodness appeals to all ages.
Great leftovers: It tastes even better the next day and freezes well for meal prep.

Ingredients You’ll Need

This Pepperjack Meatloaf Recipe uses simple, wholesome ingredients that build layers of flavor and texture—from the juicy ground beef to the spicy, creamy cheese center. Each item plays its part in making every bite absolutely delicious.

Ground beef: Choose 80/20 for the ideal fat content to keep the meatloaf juicy.
Pepperjack cheese: Cubed or shredded, it melts inside to add heat and creaminess.
Breadcrumbs: Help bind the meat and soak up moisture for tender results.
Milk: Adds moisture that keeps the meatloaf from drying out.
Egg: Acts as a binder to hold everything together firmly.
Onion and garlic: Finely chopped to infuse the meatloaf with savory aroma.
Ketchup and Worcestershire sauce: Classic savory sauces that deepen the flavor profile.
Salt and pepper: Essential for seasoning and balancing the bold cheese.
Optional chili flakes: Boosts the spice level for those who love it hot.

Variations for Pepperjack Meatloaf Recipe

This Pepperjack Meatloaf Recipe is extremely adaptable, which means it’s easy to tailor it to your preferences or dietary needs. Whether you like it milder, add veggies, or want to experiment with different meats, the possibilities are endless.

Use ground turkey or chicken: For a leaner version without sacrificing flavor.
Add finely chopped bell peppers: Incorporates extra color and sweetness to balance the spice.
Swap pepperjack for another cheese: Monterey Jack or cheddar offer a different but delicious twist.
Mix in fresh herbs: Parsley or cilantro adds a fresh herbal note.
Try a barbecue glaze: Brush the top with BBQ sauce instead of ketchup for a smoky finish.

How to Make Pepperjack Meatloaf Recipe

Step 1: Prepare Your Ingredients

Start by finely dicing the onion and garlic to release their flavors. Cube or shred your pepperjack cheese so it’s ready to mix or stuff inside the meatloaf. Preheat your oven to 350°F (175°C) while you prepare the meat mixture.

Step 2: Mix the Meat Mixture

In a large bowl, combine your ground beef, breadcrumbs, milk, egg, ketchup, Worcestershire sauce, salt, pepper, and diced onions and garlic. Use your hands or a spoon to gently mix until just combined—overmixing can make the meatloaf dense.

Step 3: Add the Pepperjack Cheese

There are two ways to incorporate the cheese: fold the cheese cubes directly into the meat mixture for pockets of melted cheese throughout, or shape half the meat mixture into a loaf base, layer the cheese cubes, then cover with the remaining meat mixture for a stuffed center.

Step 4: Shape and Bake

Form the meat mixture into a loaf shape on a baking sheet or inside a loaf pan. Brush the top with extra ketchup or your favorite glaze for a glossy finish. Bake for 55 to 65 minutes until the internal temperature reaches 160°F (71°C).

Step 5: Rest and Serve

Once out of the oven, let the meatloaf rest for 10 minutes before slicing. This helps the juices redistribute, ensuring every slice is moist and flavorful.

Pro Tips for Making Pepperjack Meatloaf Recipe

Select finely ground beef: It blends better with the other ingredients for an even texture.
Don’t skip the resting time: Resting prevents the meatloaf from falling apart and locks in moisture.
Use a meat thermometer: To avoid overcooking and drying out your meatloaf.
Add some diced vegetables: Carrots or celery finely chopped add extra nutrition without compromising flavor.
Customize the heat level: Adjust the amount of pepperjack or chili flakes according to your taste.

How to Serve Pepperjack Meatloaf Recipe

Garnishes

Sprinkle freshly chopped parsley or green onions on top for a burst of color and freshness that perfectly complements the richness of the meatloaf.

Side Dishes

Serve with creamy mashed potatoes or roasted garlic vegetables for a classic combination, or pair with a crisp salad to balance the meal.

Creative Ways to Present

Slice the meatloaf and serve open-faced sandwiches on toasted buns with lettuce, tomato, and a spread of chipotle mayo for a fun twist on meatloaf night.

Make Ahead and Storage

Storing Leftovers

Refrigerate leftover slices in an airtight container for up to 4 days to maintain freshness and flavor.

Freezing

Wrap the cooked meatloaf tightly in plastic wrap followed by foil, then freeze for up to 3 months. Thaw overnight in the refrigerator before reheating.

Reheating

Reheat slices gently in the microwave or wrap in foil and warm in a 350°F oven for 15-20 minutes to keep the meatloaf tender and melty.

FAQs

Can I use ground turkey instead of beef?

Absolutely! Ground turkey is a leaner alternative that works well for this Pepperjack Meatloaf Recipe, though you may want to add a bit more moisture like an extra egg or milk.

How spicy is pepperjack cheese?

Pepperjack has a mild to moderate heat typically from jalapeño peppers; it adds warmth without overwhelming most palates.

Can I prepare this meatloaf ahead of time?

Yes! You can mix and shape the meatloaf up to a day in advance, keep it refrigerated, then bake when ready.

What is the best way to ensure the meatloaf stays moist?

Use a combination of breadcrumbs soaked in milk and avoid overmixing the meat to keep it tender and juicy.

Can I make this gluten-free?

Yes! Replace traditional breadcrumbs with gluten-free breadcrumbs or crushed gluten-free crackers to maintain texture.

Final Thoughts

If you love comfort food with a flavorful twist, this Pepperjack Meatloaf Recipe is designed to deliver pure satisfaction with every bite. It’s easy to make, versatile, and packed with layers of cheesy, spicy goodness that transform classic meatloaf into a family favorite. Trust me, once you try it, you’ll find yourself reaching for this recipe again and again.

Pepperjack Meatloaf Recipe

Print Recipe

This Pepperjack Meatloaf Recipe offers a comforting and hearty meal with a spicy, cheesy twist. Combining classic meatloaf flavors with the bold heat and creaminess of pepperjack cheese, this dish is moist, flavorful, and kid-friendly yet packed with a mild kick. Perfect for family dinners or casual weeknights, it’s easy to prepare with simple pantry staples and results in a tender meatloaf with melted cheese pockets or a stuffed cheesy center.

Total Time: 1 hour 10-20 minutes
Yield: 6 servings 1x

Ingredients

Scale

Main Ingredients

1 ½ pounds ground beef (80/20 for juiciness)
1 cup pepperjack cheese, cubed or shredded
¾ cup breadcrumbs (use gluten-free if needed)
½ cup milk
1 large egg
½ cup ketchup, plus extra for topping
1 tablespoon Worcestershire sauce
1 small onion, finely diced
2 cloves garlic, finely minced
1 teaspoon salt
½ teaspoon black pepper
Optional: ¼ teaspoon chili flakes (to increase spice)

Instructions

Prepare Your Ingredients: Finely dice the onion and garlic to release their flavors. Cube or shred the pepperjack cheese so it’s ready to mix or stuff inside the meatloaf. Preheat your oven to 350°F (175°C) while you prepare the meat mixture.
Mix the Meat Mixture: In a large bowl, combine ground beef, breadcrumbs, milk, egg, ketchup, Worcestershire sauce, salt, pepper, and diced onions and garlic. Gently mix using your hands or a spoon until just combined—avoid overmixing to keep the loaf tender.
Add the Pepperjack Cheese: Either fold the cheese cubes directly into the meat mixture for pockets of melted cheese throughout, or shape half the meat mixture into a loaf base, layer the cheese cubes on top, then cover with the remaining meat mixture for a stuffed center.
Shape and Bake: Form the meat mixture into a loaf shape on a baking sheet or inside a loaf pan. Brush the top with extra ketchup or your preferred glaze for a glossy finish. Bake for 55 to 65 minutes until the internal temperature reaches 160°F (71°C).
Rest and Serve: Remove from the oven and let the meatloaf rest for 10 minutes before slicing. This allows the juices to redistribute, ensuring every slice is moist and flavorful.

Notes

Select finely ground beef for an even texture.
Do not skip resting time to prevent the meatloaf from falling apart and to lock in moisture.
Use a meat thermometer to avoid overcooking and drying out the meatloaf.
Adding finely diced vegetables like carrots or celery enhances nutrition without compromising flavor.
Adjust the heat level by varying the amount of pepperjack cheese or adding chili flakes according to taste.

Author: Lina
Prep Time: 15 minutes
Cook Time: 55-65 minutes
Category: Main Course
Method: Baking
Cuisine: American
Diet: Gluten Free

Nutrition

Serving Size: 1 slice (approx. 150g)
Calories: 350 kcal
Sugar: 4 g
Sodium: 650 mg
Fat: 22 g
Saturated Fat: 9 g
Unsaturated Fat: 11 g
Trans Fat: 0.5 g
Carbohydrates: 12 g
Fiber: 1 g
Protein: 25 g
Cholesterol: 95 mg

Keywords: meatloaf, pepperjack cheese, spicy meatloaf, cheesy meatloaf, comfort food, gluten free meatloaf, easy dinner